Mangonelab

Genetics and Genomics in C. elegans

Welcome to the Mangone Lab @ Arizona State University

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Let's celebrate our successful Undergraduate and Master students!

Mangonelab Undergraduate students

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Sara Keane (Undergraduate Student) Barrett Honors College
Accepted in the Biology Graduate Program at the UMass Medical School. Congratulations Sara!
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Reagan Conrad (Undergraduate Student) - Reagan joined the Ph. D. Program at the RNA Institute at the University of Albany. Congratulations Reagan!
Mangonelab Master students

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Nicholas Cuda (Master Student)
Accepted into the Molecular and Cellular Biology Program at ASU. Congratulations Nick!
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Dalton Meadows (Master Student)
Accepted into the Molecular and Cellular Biology Program at ASU. Congratulations Dalton!
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RNA transcription has been studied for more than half a century, focusing mainly on the initiation and elongation processes.
We still do not understand, however, the mechanisms of transcriptional termination, preparation of 3' mRNA ends, or the regulation of these sequences that, in turn, control gene expression at a post-transcriptional level.
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The mRNA molecule is the key intermediate of this process.
RNA is a perfect copy of the information contained in DNA, and instructs its temporal and spatial expression – producing proteins, shaping organs, timing development, and regulating biological processes in living organisms.
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Understanding how RNA transcription termination works in living organisms is very important because it will help to understand what happens in disease states such as cancer, Alzheimer’s, autism, and muscular dystrophy, all disease where this process is disrupted.
Without a deep understanding of these and other basic biological processes, our approach to human health is limited.
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The long-term goal of our laboratory is to highlight the fundamental biological mechanisms that control RNA transcription termination using a systems biology approach, taking advantage of biochemistry, high-throughput genomics, and the powerful genetics provided by the roundworm C. elegans and human cell lines.


News

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7/28/2023
Dalton Meadows (Grad Student) won the Best Poster Award (First Place) in the Gene Regulation and Genomics section at the International Worm Meeting In Glasgow. Congratulation Dalton !!!!!!


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Dr. Mangone is co-organizing a Cold Spring Harbor Asia meeting titled "The Now and Future of RNA Therapeutics" from Jun 19 - Jun 23, 2023 in Awaji, Japan. The meeting covers RNAs from basic to translation, mechanisms of RNA targeting, RNA Chemistry, the development of small RNAs, including siRNAs, LNA, PNAs, and ASOs, RNA delivery, genome editing, and preclinical and clinical programs.The abstract deadline is April 14, 2023. See you this summer in Japan!

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5/5/2023
Congratulations to Dr. Mangone for his promotion to Full Professor!!!
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5/5/2023
Congratulations to Dr. Anna Schorr

Marco Mangone, Biodesign institute at Arizona State University, 727 E. Tyler St. Tempe, AZ 85287